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EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

1.5.1.2 pyrroline-5-carboxylate reductase

1.5.1.3 dihydrofolate reductase

1.5.1.4 created 1961, deleted 1976

1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP⁺)

1.5.1.6 formyltetrahydrofolate dehydrogenase

1.5.1.7 saccharopine dehydrogenase (NAD⁺, L-lysine-forming)

1.5.1.8 saccharopine dehydrogenase (NADP⁺, L-lysine-forming)

1.5.1.9 saccharopine dehydrogenase (NAD⁺, L-glutamate-forming)

1.5.1.10 saccharopine dehydrogenase (NADP⁺, L-glutamate-forming)

1.5.1.11 D-octopine dehydrogenase

1.5.1.12 1-pyrroline-5-carboxylate dehydrogenase

1.5.1.13 created 1972, deleted 2004

1.5.1.14 created 1976, deleted 1989

1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD⁺)

1.5.1.16 D-lysopine dehydrogenase

1.5.1.17 alanopine dehydrogenase

1.5.1.18 ephedrine dehydrogenase

1.5.1.19 D-nopaline dehydrogenase

1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)

1.5.1.22 strombine dehydrogenase

1.5.1.23 tauropine dehydrogenase

1.5.1.24 N⁵-(carboxyethyl)ornithine synthase

1.5.1.25 thiomorpholine-carboxylate dehydrogenase

1.5.1.26 β-alanopine dehydrogenase

1.5.1.27 1,2-dehydroreticulinium reductase (NADPH)

1.5.1.28 opine dehydrogenase

1.5.1.29 FMN reductase [NAD(P)H]

1.5.1.30 flavin reductase (NADPH)

1.5.1.31 berberine reductase

1.5.1.32 vomilenine reductase

1.5.1.33 pteridine reductase

1.5.1.34 6,7-dihydropteridine reductase

1.5.1.35 1-pyrroline dehydrogenase

1.5.1.36 flavin reductase (NADH)

1.5.1.37 FAD reductase (NADH)

1.5.1.38 FMN reductase (NADPH)

1.5.1.39 FMN reductase [NAD(P)H]

1.5.1.40 8-hydroxy-5-deazaflavin:NADPH oxidoreductase

1.5.1.41 riboflavin reductase [NAD(P)H]

1.5.1.42 FMN reductase (NADH)

1.5.1.43 carboxynorspermidine synthase

1.5.1.44 festuclavine dehydrogenase

1.5.1.45 FAD reductase [NAD(P)H]

1.5.1.46 agroclavine dehydrogenase

1.5.1.47 dihydromethanopterin reductase [NAD(P)⁺]

1.5.1.48 2-methyl-1-pyrroline reductase

1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]

1.5.1.50 dihydromonapterin reductase

1.5.1.51 N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate dehydrogenase

1.5.1.52 staphylopine dehydrogenase

1.5.1.53 methylenetetrahydrofolate reductase (NADPH)

1.5.1.54 methylenetetrahydrofolate reductase (NADH)

1.5.3 With oxygen as acceptor

1.5.4 With a disulfide as acceptor

1.5.5 With a quinone or similar compound as acceptor

1.5.7 With an iron-sulfur protein as acceptor

1.5.8 With a flavin or flavoprotein as acceptor

1.5.98 With other, known, physiological acceptors

1.5.99 With unknown physiological acceptors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.1. undefined

1.13.11 With incorporation of two atoms of oxygen

1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

1.13.99 Miscellaneous

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

3.1 Acting on ester bonds

3.2 Glycosylases

3.3 Acting on ether bonds

3.4 Acting on peptide bonds (peptidases)

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.1 asparaginase

3.5.1.2 glutaminase

3.5.1.3 ω-amidase

3.5.1.4 amidase

3.5.1.6 β-ureidopropionase

3.5.1.7 ureidosuccinase

3.5.1.8 formylaspartate deformylase

3.5.1.9 arylformamidase

3.5.1.10 formyltetrahydrofolate deformylase

3.5.1.11 penicillin amidase

3.5.1.12 biotinidase

3.5.1.13 aryl-acylamidase

3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase

3.5.1.15 aspartoacylase

3.5.1.16 acetylornithine deacetylase

3.5.1.17 acyl-lysine deacylase

3.5.1.18 succinyl-diaminopimelate desuccinylase

3.5.1.19 nicotinamidase

3.5.1.20 citrullinase

3.5.1.21 N-acetyl-β-alanine deacetylase

3.5.1.22 pantothenase

3.5.1.23 ceramidase

3.5.1.24 choloylglycine hydrolase

3.5.1.25 N-acetylglucosamine-6-phosphate deacetylase

3.5.1.26 N⁴-(β-N-acetylglucosaminyl)-L-asparaginase

3.5.1.27 N-formylmethionylaminoacyl-tRNA deformylase

3.5.1.28 N-acetylmuramoyl-L-alanine amidase

3.5.1.29 2-(acetamidomethylene)succinate hydrolase

3.5.1.30 5-aminopentanamidase

3.5.1.31 formylmethionine deformylase

3.5.1.32 hippurate hydrolase

3.5.1.33 N-acetylglucosamine deacetylase

3.5.1.34 created 1972, deleted 1981

3.5.1.35 D-glutaminase

3.5.1.36 N-methyl-2-oxoglutaramate hydrolase

3.5.1.37 created 1972, deleted 1976

3.5.1.38 glutamin-(asparagin-)ase

3.5.1.39 alkylamidase

3.5.1.40 acylagmatine amidase

3.5.1.41 chitin deacetylase

3.5.1.42 nicotinamide-nucleotide amidase

3.5.1.43 peptidyl-glutaminase

3.5.1.44 protein-glutamine glutaminase

3.5.1.45 created 1978, deleted 1986

3.5.1.46 6-aminohexanoate-oligomer exohydrolase

3.5.1.47 N-acetyldiaminopimelate deacetylase

3.5.1.48 acetylspermidine deacetylase

3.5.1.49 formamidase

3.5.1.50 pentanamidase

3.5.1.51 4-acetamidobutyryl-CoA deacetylase

3.5.1.52 peptide-N⁴-(N-acetyl-β-glucosaminyl)asparagine amidase

3.5.1.53 N-carbamoylputrescine amidase

3.5.1.54 allophanate hydrolase

3.5.1.55 long-chain-fatty-acyl-glutamate deacylase

3.5.1.56 N,N-dimethylformamidase

3.5.1.57 tryptophanamidase

3.5.1.58 N-benzyloxycarbonylglycine hydrolase

3.5.1.59 N-carbamoylsarcosine amidase

3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase

3.5.1.61 mimosinase

3.5.1.62 acetylputrescine deacetylase

3.5.1.63 4-acetamidobutyrate deacetylase

3.5.1.64 N^α-benzyloxycarbonylleucine hydrolase

3.5.1.65 theanine hydrolase

3.5.1.66 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

3.5.1.67 4-methyleneglutaminase

3.5.1.68 N-formylglutamate deformylase

3.5.1.69 glycosphingolipid deacylase

3.5.1.70 aculeacin-A deacylase

3.5.1.71 N-feruloylglycine deacylase

3.5.1.72 D-benzoylarginine-4-nitroanilide amidase

3.5.1.73 carnitinamidase

3.5.1.74 chenodeoxycholoyltaurine hydrolase

3.5.1.75 urethanase

3.5.1.76 arylalkyl acylamidase

3.5.1.77 N-carbamoyl-D-amino-acid hydrolase

3.5.1.78 glutathionylspermidine amidase

3.5.1.79 phthalyl amidase

3.5.1.80 created 1999, deleted 2002

3.5.1.81 N-acyl-D-amino-acid deacylase

3.5.1.82 N-acyl-D-glutamate deacylase

3.5.1.83 N-acyl-D-aspartate deacylase

3.5.1.84 biuret amidohydrolase

3.5.1.85 (S)-N-acetyl-1-phenylethylamine hydrolase

3.5.1.86 mandelamide amidase

3.5.1.87 N-carbamoyl-L-amino-acid hydrolase

3.5.1.88 peptide deformylase

3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase

3.5.1.90 adenosylcobinamide hydrolase

3.5.1.91 N-substituted formamide deformylase

3.5.1.92 pantetheine hydrolase

3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase

3.5.1.94 γ-glutamyl-γ-aminobutyrate hydrolase

3.5.1.95 N-malonylurea hydrolase

3.5.1.96 succinylglutamate desuccinylase

3.5.1.97 acyl-homoserine-lactone acylase

3.5.1.98 histone deacetylase

3.5.1.99 fatty acid amide hydrolase

3.5.1.100 (R)-amidase

3.5.1.101 L-proline amide hydrolase

3.5.1.102 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5′-monophosphate deformylase

3.5.1.103 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase

3.5.1.104 peptidoglycan-N-acetylglucosamine deacetylase

3.5.1.105 chitin disaccharide deacetylase

3.5.1.106 N-formylmaleamate deformylase

3.5.1.107 maleamate amidohydrolase

3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase

3.5.1.109 sphingomyelin deacylase

3.5.1.110 ureidoacrylate amidohydrolase

3.5.1.111 2-oxoglutaramate amidase

3.5.1.112 2′-N-acetylparomamine deacetylase

3.5.1.113 2′′′-acetyl-6′′′-hydroxyneomycin C deacetylase

3.5.1.114 N-acyl-aromatic-L-amino acid amidohydrolase

3.5.1.115 mycothiol S-conjugate amidase

3.5.1.116 ureidoglycolate amidohydrolase

3.5.1.117 6-aminohexanoate-oligomer endohydrolase

3.5.1.118 γ-glutamyl hercynylcysteine S-oxide hydrolase

3.5.1.119 Pup amidohydrolase

3.5.1.120 2-aminomuconate deaminase (2-hydroxymuconate-forming)

3.5.1.121 protein N-terminal asparagine amidohydrolase

3.5.1.122 protein N-terminal glutamine amidohydrolase

3.5.1.123 γ-glutamylanilide hydrolase

3.5.1.124 protein deglycase

3.5.1.125 N²-acetyl-L-2,4-diaminobutanoate deacetylase

3.5.1.126 oxamate amidohydrolase

3.5.1.127 jasmonoyl-L-amino acid hydrolase

3.5.1.128 deaminated glutathione amidase

3.5.1.129 N⁵-(cytidine 5′-diphosphoramidyl)-L-glutamine hydrolase

3.5.1.130 [amino group carrier protein]-lysine hydrolase

3.5.1.131 1-carboxybiuret hydrolase

3.5.1.132 [amino group carrier protein]-ornithine hydrolase

3.5.1.133 N^α-acyl-L-glutamine aminoacylase

3.5.1.134 (indol-3-yl)acetyl-L-aspartate hydrolase

3.5.1.135 N⁴-acetylcytidine amidohydrolase

3.5.1.136 N,N′-diacetylchitobiose non-reducing end deacetylase

3.5.1.137 N-methylcarbamate hydrolase

3.5.2 In cyclic amides

3.5.3 In linear amidines

3.5.4 In cyclic amidines

3.5.5 In nitriles

3.5.99 In other compounds

3.6 Acting on acid anhydrides

3.7 Acting on carbon-carbon bonds

3.8 Acting on halide bonds

3.9 Acting on phosphorus-nitrogen bonds

3.10 Acting on sulfur-nitrogen bonds

3.10.1 Acting on sulfur-nitrogen bonds (only sub-subclass identified to date)

3.11 Acting on carbon-phosphorus bonds

3.12 Acting on sulfur-sulfur bonds

3.13 Acting on carbon-sulfur bonds

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Release 2023.1 (January 2023)