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EC 1.12.1.3 Details
show Brenda entryEC number
1.12.1.3
Accepted name
hydrogen dehydrogenase (NADP+)
Reaction
H2 + NADP+ = H+ + NADPH
Other name(s)
NADP+-linked hydrogenase,
NADP+-reducing hydrogenase,
hydrogenase (ambiguous),
hydrogenase I (ambiguous)
Systematic name
hydrogen:NADP+ oxidoreductase
CAS registry number
9027-05-8
Comment
The protein from the bacterium Desulfovibrio fructosovorans is an iron-sulfur protein that exclusively functions as a hydrogen dehydrogenase [1], while the enzyme from the archaeon Pyrococcus furiosus is a nickel, iron, iron-sulfur protein, that is part of a heterotetrameric complex where the α and δ subunits function as a hydrogenase while the β and γ subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.5, hydrogen dehydrogenase [NAD(P)+].
History
created 2002, modified 2013
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.13.11.21 created 1972, deleted 2001 1.13.12.10 created 1989, modified 1999, deleted 2001
