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EC 6.3.2.57 Details
EC number
6.3.2.57
Accepted name
staphyloferrin A synthase
Reaction
ATP + N5-[(S)-citryl]-D-ornithine + citrate = AMP + diphosphate + staphyloferrin A
Other name(s)
sfnaB (gene name)
Systematic name
N5-[(S)-citryl]-D-ornithine:citrate ligase (staphyloferrin A-forming)
Comment
Requires Mg2+. The enzyme, characterized from the bacterium Staphylococcus aureus, catalyses the last step in the biosynthesis of the siderophore staphyloferrin A. It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS). Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate. The enzyme forms a citrate adenylate intermediate prior to ligation.
History
created 2019
EC Tree
1.13.11.7 created 1965 as EC 1.13.1.7, transferred 1972 to EC 1.13.11.7, deleted 1980
1.13.11.21 created 1972, deleted 2001