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EC 2.7.11.31 Details
show Brenda entryEC number
2.7.11.31
Accepted name
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
Reaction
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Other name(s)
AMPK,
AMP-activated protein kinase,
HMG-CoA reductase kinase,
β-hydroxy-β-methylglutaryl-CoA reductase kinase,
[hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase,
3-hydroxy-3-methylglutaryl coenzyme A reductase kinase,
3-hydroxy-3-methylglutaryl-CoA reductase kinase,
hydroxymethylglutaryl coenzyme A reductase kinase,
hydroxymethylglutaryl coenzyme A reductase kinase (phosphorylating),
hydroxymethylglutaryl-CoA reductase kinase,
reductase kinase,
STK29
Systematic name
ATP:[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphotransferase
CAS registry number
172522-01-9
Comment
The enzyme is activated by AMP. EC 1.1.1.34, hydroxymethylglutaryl-CoA reductase (NADPH) is inactivated by the phosphorylation of the enzyme protein. Histones can also act as acceptors. The enzyme can also phosphorylate hepatic acetyl-CoA carboxylase (EC 6.4.1.2) and adipose hormone-sensitive lipase (EC 3.1.1.79) [5]. Thr-172 within the catalytic subunit (α-subunit) is the major site phosphorylated by the AMP-activated protein kinase kinase [7]. GTP can act instead of ATP [4]
History
created 1984 as EC 2.7.1.109, transferred 2005 to EC 2.7.11.31
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.13.11.21 created 1972, deleted 2001
