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EC 1.13.11.11 Details
show Brenda entryEC number
1.13.11.11
Accepted name
tryptophan 2,3-dioxygenase
Reaction
L-tryptophan + O2 = N-formyl-L-kynurenine
Other name(s)
tryptophan pyrrolase (ambiguous),
tryptophanase,
tryptophan oxygenase,
tryptamine 2,3-dioxygenase,
tryptophan peroxidase,
indoleamine 2,3-dioxygenase (ambiguous),
indolamine 2,3-dioxygenase (ambiguous),
L-tryptophan pyrrolase,
TDO,
L-tryptophan 2,3-dioxygenase,
L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Systematic name
L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)
CAS registry number
9014-51-1
Comment
A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2].
History
created 1961 as EC 1.11.1.4, deleted 1964, reinstated 1965 as EC 1.13.1.12, transferred 1972 to EC 1.13.11.11, modified 1989, modified 2006
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.13.11.21 created 1972, deleted 2001
