EC Explorer

2.1.1.167

27S pre-rRNA (guanosine²⁹²²-2′-O)-methyltransferase

S-adenosyl-L-methionine + guanosine²⁹²² in 27S pre-rRNA = S-adenosyl-L-homocysteine + 2′-O-methylguanosine²⁹²² in 27S pre-rRNA

Spb1p (gene name), YCL054W (gene name)

S-adenosyl-L-methionine:27S pre-rRNA (guanosine²⁹²²-2′-O-)-methyltransferase

Spb1p is a site-specific 2′-O-ribose RNA methyltransferase that catalyses the formation of 2′-O-methylguanosine²⁹²², a universally conserved position of the catalytic center of the ribosome that is essential for translation. 2′-O-Methylguanosine²⁹²² is formed at a later stage of the processing, during the maturation of of the 27S pre-rRNA. In absence of snR52, Spb1p can also catalyse the formation of uridine²⁹²¹ [1].

created 2010