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EC 5.4.2.12 Details
EC number
5.4.2.12
Accepted name
phosphoglycerate mutase (2,3-diphosphoglycerate-independent)
Reaction
2-phospho-D-glycerate = 3-phospho-D-glycerate
Other name(s)
cofactor independent phosphoglycerate mutase, 2,3-diphosphoglycerate-independent phosphoglycerate mutase, phosphoglycerate phosphomutase (ambiguous), phosphoglyceromutase (ambiguous), monophosphoglycerate mutase (ambiguous), monophosphoglyceromutase (ambiguous), GriP mutase (ambiguous), PGA mutase (ambiguous), iPGM, iPGAM, PGAM-i
Systematic name
D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-independent)
Comment
The enzymes from higher plants, algae, some fungi, nematodes, sponges, coelenterates, myriapods, arachnids, echinoderms, archaea and some bacteria (particularly Gram-positive) have maximum activity in the absence of 2,3-bisphospho-D-glycerate. cf. EC 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent). The enzyme contains two Mn2+ (or in some species two Co2+ ions). The reaction involves a phosphotransferase reaction to serine followed by transfer back to the glycerate at the other position. Both metal ions are involved in the reaction.
History
created 2013
EC Tree
1.13.11.7 created 1965 as EC 1.13.1.7, transferred 1972 to EC 1.13.11.7, deleted 1980
1.13.11.21 created 1972, deleted 2001