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EC 2.1.1.346 Details
EC number
2.1.1.346
Accepted name
U6 snRNA m6A methyltransferase
Reaction
S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N6-methyladenine in U6 snRNA
Other name(s)
METTL16 (gene name)
Systematic name
S-adenosyl-L-methionine:adenine in U6 snRNA methyltransferase
Comment
This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions [2].
History
created 2018
EC Tree
1.13.11.7 created 1965 as EC 1.13.1.7, transferred 1972 to EC 1.13.11.7, deleted 1980
1.13.11.21 created 1972, deleted 2001