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EC 1.8.4.6 Details

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EC number

1.8.4.6

Accepted name

protein-methionine-S-oxide reductase

Reaction

protein L-methionine + thioredoxin disulfide = protein L-methionine S-oxide + thioredoxin

Other name(s)

methionine sulfoxide (protein) reductase, methionine sulfoxide peptide reductase, protein (methionine sulfoxide) reductase, Met(O)-peptide reductase, peptide methionine sulfoxide reductase, protein-L-methionine:oxidized-thioredoxin S-oxidoreductase

Systematic name

protein-L-methionine:thioredoxin-disulfide S-oxidoreductase

CAS registry number

78206-57-2

Comment

Dithiothreitol, but not 2-mercaptoethanol, can replace a reduced thioredoxin in the reverse reaction. Does not act on free methionine (cf. EC 1.8.4.5 methionine-S-oxide reductase)

History

created 1984, deleted 2006

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.9.3 With oxygen as acceptor

1.9.6 With a nitrogenous group as acceptor

1.9.98 With other, known, physiological acceptors

1.9.99 With unknown physiological acceptors

1.9.99.1 iron—cytochrome-c reductase

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.16.1 With NAD⁺ or NADP⁺ as acceptor

1.16.3 With oxygen as acceptor

1.16.5 With a quinone or similar compound as acceptor

1.16.8 With a flavin as acceptor

1.16.9 With a copper protein as acceptor

1.16.98 With other, known, physiological acceptors

1.16.99 With unknown physiological acceptors

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.22.1 With NAD⁺ or NADP⁺ as acceptor

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)