EC Explorer

2.4.2.42

UDP-D-xylose:β-D-glucoside α-1,3-D-xylosyltransferase

UDP-α-D-xylose + [protein with EGF-like domain]-3-O-(β-D-glucosyl)-L-serine = UDP + [protein with EGF-like domain]-3-O-[α-D-xylosyl-(1→3)-β-D-glucosyl]-L-serine

β-glucoside α-1,3-xylosyltransferase, UDP-α-D-xylose:β-D-glucoside 3-α-D-xylosyltransferase, GXYLT1 (gene name), GXYLT2 (gene name)

UDP-α-D-xylose:[protein with EGF-like domain]-3-O-(β-D-glucosyl)-L-serine 3-α-D-xylosyltransferase (configuration-retaining)

The enzyme, found in animals and insects, is involved in the biosynthesis of the α-D-xylosyl-(1→3)-α-D-xylosyl-(1→3)-β-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-like) domains [2,3]. When present on Notch proteins, the trisaccharide functions as a modulator of the signalling activity of this protein.

created 2010, modified 2020