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EC 1.6.2.4 Details
EC number
1.6.2.4
Accepted name
NADPH—hemoprotein reductase
Reaction
NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein
Other name(s)
CPR, FAD-cytochrome c reductase, NADP-cytochrome c reductase, NADP-cytochrome reductase, NADPH-dependent cytochrome c reductase, NADPH:P-450 reductase, NADPH:ferrihemoprotein oxidoreductase, NADPH—cytochrome P-450 oxidoreductase, NADPH-cytochrome c oxidoreductase, NADPH-cytochrome c reductase, NADPH—cytochrome p-450 reductase, NADPH-ferricytochrome c oxidoreductase, NADPH-ferrihemoprotein reductase, TPNH2 cytochrome c reductase, TPNH-cytochrome c reductase, aldehyde reductase (NADPH-dependent), cytochrome P-450 reductase, cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent), dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase, ferrihemoprotein P-450 reductase, reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase, reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate)
Systematic name
NADPH:hemoprotein oxidoreductase
CAS registry number
9023-03-4
Comment
A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases (e.g. EC 1.14.14.1, unspecific monooxygenase) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. It also reduces cytochrome b5 and cytochrome c. The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
History
created 1972, modified 2003
EC Tree
1.6.99.2 created 1961 as EC 1.6.5.2, transferred 1965 to EC 1.6.99.2, deleted 2005
1.6.99.4 created 1965, deleted 1972
1.6.99.7 created 1972, modified 1981 (EC 1.6.99.10 created 1978, incorporated 1981), deleted 2003
1.6.99.8 created 1972, deleted 2002
1.6.99.9 created 1972, deleted 2002
1.6.99.10 created 1978, deleted 1981
1.6.99.11 created 1989, deleted 2002
1.6.99.12 created 1989, deleted 2002
1.6.99.13 created 1992, deleted 2002