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EC 3.1.12.1 Details

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EC number

3.1.12.1

Accepted name

5′ to 3′ exodeoxyribonuclease (nucleoside 3′-phosphate-forming)

Reaction

exonucleolytic cleavage in the 5′- to 3′-direction to yield nucleoside 3′-phosphates

Other name(s)

Cas4, 5&prime, to 3&prime, single stranded DNA exonuclease

Comment

Preference for single-stranded DNA. The enzyme from the archaeon Sulfolobus solfataricus contains a [4Fe-4S] cluster and requires a divalent metal cation, such as Mg²⁺ or Mn²⁺, for activity.

History

created 2014

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.2.1 With NAD⁺ or NADP⁺ as acceptor

1.2.2 With a cytochrome as acceptor

1.2.3 With oxygen as acceptor

1.2.4 With a disulfide as acceptor

1.2.5 With a quinone or similar compound as acceptor

1.2.7 With an iron-sulfur protein as acceptor

1.2.98 With other, known, physiological acceptors

1.2.99 With unknown physiological acceptors

1.2.99.1 created 1961, deleted 1984

1.2.99.2 carbon-monoxide dehydrogenase (acceptor)

1.2.99.3 aldehyde dehydrogenase (pyrroloquinoline-quinone)

1.2.99.4 formaldehyde dismutase

1.2.99.5 formylmethanofuran dehydrogenase

1.2.99.6 carboxylate reductase

1.2.99.7 aldehyde dehydrogenase (FAD-independent)

1.2.99.8 glyceraldehyde dehydrogenase (FAD-containing)

1.2.99.9 formate dehydrogenase (coenzyme F₄₂₀)

1.2.99.10 4,4′-diapolycopenoate synthase

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.8.1 With NAD⁺ or NADP⁺ as acceptor

1.8.2 With a cytochrome as acceptor

1.8.3 With oxygen as acceptor

1.8.4 With a disulfide as acceptor

1.8.5 With a quinone or similar compound as acceptor

1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

1.8.7 With an iron-sulfur protein as acceptor

1.8.98 With other, known, physiological acceptors

1.8.99 With unknown physiological acceptors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.98.1. undefined

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)