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EC 2.3.1.239 Details
EC number
2.3.1.239
Accepted name
10-deoxymethynolide synthase
Reaction
malonyl-CoA + 5 (2S)-methylmalonyl-CoA + 5 NADPH + 5 H+ = 10-deoxymethynolide + 6 CoA + 6 CO2 + 5 NADP+ + 2 H2O
Other name(s)
pikromycin PKS
Systematic name
(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide-forming)
Comment
The product, 10-deoxymethynolide, contains a 12-membered ring and is an intermediate in the biosynthesis of methymycin in the bacterium Streptomyces venezuelae. The enzyme also produces narbonolide (see EC 2.3.1.240, narbonolide synthase). The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain. Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP). Not all active sites are used in the biosynthesis.
History
created 2014
EC Tree
1.14.99.5 created 1972, modified 1986, modified 2000, deleted 2000
1.14.99.6 created 1972, modified 2000, deleted 2000
1.14.99.8 created 1972, deleted 1984
1.14.99.13 created 1972, deleted 1984
1.14.99.16 created 1972, deleted 2002
1.14.99.17 created 1972, deleted 1976
1.14.99.18 created 1976, modified 1999, deleted 2003
1.14.99.25 created 1986, deleted 2000