EC Explorer

2.1.1.179

16S rRNA (guanine¹⁴⁰⁵-N⁷)-methyltransferase

S-adenosyl-L-methionine + guanine¹⁴⁰⁵ in 16S rRNA = S-adenosyl-L-homocysteine + N⁷-methylguanine¹⁴⁰⁵ in 16S rRNA

methyltransferase Sgm, m⁷G¹⁴⁰⁵ Mtase, Sgm Mtase, Sgm, sisomicin-gentamicin methyltransferase, sisomicin-gentamicin methylase, GrmA, RmtB, RmtC, ArmA

S-adenosyl-L-methionine:16S rRNA (guanine¹⁴⁰⁵-N⁷)-methyltransferase

The enzyme from the antibiotic-producing bacterium Micromonospora zionensis specifically methylates guanine¹⁴⁰⁵ at N⁷ in 16S rRNA, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins [2].

created 2010