EC Explorer

1.14.21.3

berbamunine synthase

(S)-N-methylcoclaurine + (R)-N-methylcoclaurine + NADPH + H⁺ + O₂ = berbamunine + NADP⁺ + 2 H₂O

(S)-N-methylcoclaurine oxidase (C-O phenol-coupling)

(S)-N-methylcoclaurine,NADPH:oxygen oxidoreductase (C-O phenol-coupling)

144941-42-4

A heme-thiolate enzyme (P-450). Forms the bisbenzylisoquinoline alkaloid berbamunine by phenol oxidation of N-methylcoclaurine without the incorporation of oxygen into the product. Reaction of two molecules of (R)-N-methylcoclaurine gives the dimer guattagaumerine.

created 2002, deleted 2018