EC Explorer

1.14.17.3

peptidylglycine monooxygenase

[peptide]-glycine + 2 ascorbate + O₂ = [peptide]-(2S)-2-hydroxyglycine + 2 monodehydroascorbate + H₂O

peptidylglycine 2-hydroxylase, peptidyl α-amidating enzyme, peptide-α-amide synthetase, peptide α-amidating enzyme, peptide α-amide synthase, peptidylglycine α-hydroxylase, peptidylglycine α-amidating monooxygenase, PAM-A, PAM-B, PAM, peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)

[peptide]-glycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)

90597-47-0

A copper protein. The enzyme binds two copper ions with distinct roles during catalysis. Peptidylglycines with a neutral amino acid residue in the penultimate position are the best substrates for the enzyme. The product is unstable and dismutates to glyoxylate and the corresponding desglycine peptide amide, a reaction catalysed by EC 4.3.2.5 peptidylamidoglycolate lyase. In mammals, the two activities are part of a bifunctional protein. Involved in the final step of biosynthesis of α-melanotropin and related biologically active peptides.

created 1989, modified 2019