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EC 4.2.1.167 Details
EC number
4.2.1.167
Accepted name
(R)-2-hydroxyglutaryl-CoA dehydratase
Reaction
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
Other name(s)
hgdAB (gene names)
Systematic name
(R)-2-hydroxyglutaryl-CoA hydro-lyase ((E)-glutaconyl-CoA-forming)
Comment
The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate. The enzyme contains [4Fe-4S] clusters, FMNH2 and riboflavin. It must be activated by an activator protein. Once activated, it can catalyse many turnovers.
History
created 2016
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