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EC 1.1.1.387 Details
show Brenda entryEC number
1.1.1.387
Accepted name
L-serine 3-dehydrogenase (NAD+)
Reaction
L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction);; (1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+;; (1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous)
Other name(s)
NAD+-dependent L-serine dehydrogenase
Systematic name
L-serine:NAD+ 3-oxidoreductase
Comment
The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP+)].
History
created 2015
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.19.1 stearoyl-CoA 9-desaturase
