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EC 4.4.1.36 Details
EC number
4.4.1.36
Accepted name
hercynylcysteine S-oxide lyase
Reaction
S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + NH3 + acceptor (overall reaction);;(1a) S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-(hydroxysulfanyl)hercynine + pyruvate + NH3;;(1b) 2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O (spontaneous)
Other name(s)
egtE (gene name)
Systematic name
S-(hercyn-2-yl)-L-cysteine ergothioneine-hydroxysulfanolate-lyase
Comment
Contains pyridoxal 5′-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-(hydroxysulfanyl)hercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function.
History
created 2017
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