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EC 1.1.1.393 Details
EC number
1.1.1.393
Accepted name
3β-hydroxycholanate 3-dehydrogenase (NADP+)
Reaction
isolithocholate + NADP+ = 3-oxo-5β-cholan-24-oate + NADPH + H+
Other name(s)
3β-hydroxysteroid dehydrogenase (ambiguous)
Systematic name
isolithocholate:NADP+ 3-oxidoreductase
Comment
This bacterial enzyme is involved, along with EC 1.1.1.52, 3α-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3α-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3β-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3β-hydroxycholanate 3-dehydrogenase (NAD+).
History
created 2016
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