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EC 4.99.1.8 Details
EC number
4.99.1.8
Accepted name
heme ligase
Reaction
2 ferriprotoporphyrin IX = β-hematin
Other name(s)
heme detoxification protein, HDP, hemozoin synthase
Systematic name
Fe3+:ferriprotoporphyrin IX ligase (β-hematin-forming)
Comment
This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme.
History
created 2009
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