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EC 1.14.14.105 Details
show Brenda entryEC number
1.14.14.105
Accepted name
taxane 10β-hydroxylase
Reaction
taxa-4(20),11-dien-5α-yl acetate + [reduced NADPH—hemoprotein reductase] + O2 = 10β-hydroxytaxa-4(20),11-dien-5α-yl acetate + [oxidized NADPH—hemoprotein reductase] + H2O
Other name(s)
CYP725A1 (gene name),
5-α-taxadienol-10-β-hydroxylase
Systematic name
taxa-4(20),11-dien-5α-yl acetate,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (10β-hydroxylating)
CAS registry number
337514-75-7
Comment
This microsomal cytochrome-P-450 (heme-thiolate) enzyme from the plant Taxus cuspidata is involved in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel).
History
created 2002 as EC 1.14.13.76, transferred 2018 to EC 1.14.14.105
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.14.2 created 1972, deleted 1976 1.14.14.4 created 2000, deleted 2002
