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EC 6.3.1.19 Details
EC number
6.3.1.19
Accepted name
prokaryotic ubiquitin-like protein ligase
Reaction
ATP + [prokaryotic ubiquitin-like protein]-L-glutamate + [protein]-L-lysine = ADP + phosphate + N6-([prokaryotic ubiquitin-like protein]-γ-L-glutamyl)-[protein]-L-lysine
Other name(s)
PafA (ambiguous), Pup ligase, proteasome accessory factor A
Systematic name
[prokaryotic ubiquitin-like protein]:[protein]-L-lysine
Comment
The enzyme has been characterized from the bacteria Mycobacterium tuberculosis and Corynebacterium glutamicum. It catalyses the ligation of the prokaryotic ubiquitin-like protein (Pup) to a target protein by forming a bond between an ε-amino group of a lysine residue of the target protein and the γ-carboxylate of the C-terminal glutamate of the ubiquitin-like protein (Pup). The attachment of Pup, also known as Pupylation, marks proteins for proteasomal degradation.
History
created 2015
EC Tree
1.14.14.2 created 1972, deleted 1976
1.14.14.4 created 2000, deleted 2002