EC Explorer
[browse EC tree] - [search]
EC 4.3.2.7 Details
show Brenda entryEC number
4.3.2.7
Accepted name
glutathione-specific γ-glutamylcyclotransferase
Reaction
glutathione = L-cysteinylglycine + 5-oxo-L-proline
Other name(s)
γ-GCG,
CHAC (gene name),
CHAC1 (gene name),
CHAC2 (gene name)
Systematic name
glutathione γ-glutamyl cyclotransferase (5-oxo-L-proline producing)
Comment
The enzyme, found in bacteria, fungi and animals, is specific for glutathione (cf. EC 4.3.2.9, γ-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
History
created 2017
back to topEC Tree
1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
