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EC 1.1.1.328 Details
EC number
1.1.1.328
Accepted name
nicotine blue oxidoreductase
Reaction
3,3′-bipyridine-2,2′,5,5′,6,6′-hexol + NAD(P)+ = (E)-2,2′,5,5′-tetrahydroxy-6H,6′H-[3,3′-bipyridinylidene]-6,6′-dione + NAD(P)H + H+
Other name(s)
nboR (gene name)
Systematic name
3,3′-bipyridine-2,2′,5,5′,6,6′-hexol:NADP+ 11-oxidoreductase
Comment
The enzyme, characterized from the nicotine degrading bacterium Arthrobacter nicotinovorans, catalyses the reduction of "nicotine blue" to its hydroquinone form (the opposite direction from that shown). Nicotine blue is the name given to the compound formed by the autocatalytic condensation of two molecules of 2,3,6-trihydroxypyridine, an intermediate in the nicotine degradation pathway. The main role of the enzyme may be to prevent the intracellular formation of nicotine blue semiquinone radicals, which by redox cycling would lead to the formation of toxic reactive oxygen species. The enzyme possesses a slight preference for NADH over NADPH.
History
created 2012
EC Tree
1.14.13.45 created 1992, deleted 2003