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EC 1.14.13.41 Details
show Brenda entryEC number
1.14.13.41
Accepted name
tyrosine N-monooxygenase
Reaction
L-tyrosine + 2 O2 + 2 NADPH + 2 H+ = (E)-[4-hydroxyphenylacetaldehyde oxime] + 2 NADP+ + CO2 + 3 H2O (overall reaction);;(1a) L-tyrosine + O2 + NADPH + H+ = N-hydroxy-L-tyrosine + NADP+ + H2O;;(1b) N-hydroxy-L-tyrosine + O2 + NADPH + H+ = N,N-dihydroxy-L-tyrosine + NADP+ + H2O;;(1c) N,N-dihydroxy-L-tyrosine = (E)-[4-hydroxyphenylacetaldehyde oxime] + CO2 + H2O (spontaneous)
Other name(s)
tyrosine N-hydroxylase,
CYP79A1
Systematic name
L-tyrosine,NADPH:oxygen oxidoreductase (N-hydroxylating)
CAS registry number
159447-19-5
Comment
A P-450 (heme-thiolate) protein. This enzyme is involved in the biosynthesis of the cyanogenic glucoside dhurrin in sorghum, along with EC 1.14.13.68, 4-hydroxyphenylacetaldehyde oxime monooxygenase and EC 2.4.1.85, cyanohydrin β-glucosyltransferase. Some 2-(4-hydroxyphenyl)-1-nitroethane is formed as a side product.
History
created 1992, modified 2001, modified 2005, deleted 2016
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
