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EC 1.14.13.22 Details
show Brenda entryEC number
1.14.13.22
Accepted name
cyclohexanone monooxygenase
Reaction
cyclohexanone + NADPH + H+ + O2 = hexano-6-lactone + NADP+ + H2O
Other name(s)
cyclohexanone 1,2-monooxygenase,
cyclohexanone oxygenase,
cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing)
Systematic name
cyclohexanone,NADPH:oxygen oxidoreductase (lactone-forming)
CAS registry number
52037-90-8
Comment
A flavoprotein (FAD). In the catalytic mechanism of this enzyme, the nucleophilic species that attacks the carbonyl group is a peroxyflavin intermediate that is generated by reaction of the enzyme-bound flavin cofactor with NAD(P)H and oxygen [2]. This enzyme is able to catalyse a wide range of oxidative reactions, including enantioselective Baeyer-Villiger reactions [3], sulfoxidations [4], amine oxidations [5] and epoxidations [6].
History
created 1984, modified 2004
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.14.13.45 created 1992, deleted 2003
