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EC 1.3.99.8 Details
EC number
1.3.99.8
Accepted name
2-furoyl-CoA dehydrogenase
Reaction
2-furoyl-CoA + H2O + acceptor = S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor
Other name(s)
furoyl-CoA hydroxylase, 2-furoyl coenzyme A hydroxylase, 2-furoyl coenzyme A dehydrogenase, 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating)
Systematic name
2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating)
CAS registry number
9068-18-2
Comment
A copper protein. The oxygen atom of the -OH produced is derived from water, not O2; the actual oxidative step is probably dehydrogenation of a hydrated form -CHOH-CH2- to -C(OH)=CH-, which tautomerizes non-enzymically to -CO-CH2-, giving (5-oxo-4,5-dihydro-2-furoyl)-CoA. Methylene blue, nitro blue, tetrazolium and a membrane fraction from Pseudomonas putida can act as acceptors.
History
created 1976
EC Tree
1.3.99.9 created 1976, deleted 2002