EC Explorer

[browse EC tree] - [search]

EC 2.1.1.188 Details

show Brenda entry

EC number

2.1.1.188

Accepted name

23S rRNA (guanine⁷⁴⁸-N¹)-methyltransferase

Reaction

S-adenosyl-L-methionine + guanine⁷⁴⁸ in 23S rRNA = S-adenosyl-L-homocysteine + N¹-methylguanine⁷⁴⁸ in 23S rRNA

Other name(s)

Rlma(II), Rlma2, 23S rRNA m¹G⁷⁴⁸ methyltransferase, RlmaII, Rlma II, tylosin-resistance methyltransferase RlmA(II), TlrB, rRNA large subunit methyltransferase II

Systematic name

S-adenosyl-L-methionine:23S rRNA (guanine⁷⁴⁸-N¹)-methyltransferase

Comment

The enzyme specifically methylates guanine⁷⁴⁸ at N¹ in 23S rRNA. The methyltransferase RlmA^II confers resistance to the macrolide antibiotic tylosin in the drug-producing strain Streptomyces fradiae [1].

History

created 1976 as EC 2.1.1.51, part transferred 2010 to EC 2.1.1.188

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.2 With a cytochrome as acceptor

1.3.3 With oxygen as acceptor

1.3.4 With a disulfide as acceptor

1.3.5 With a quinone or related compound as acceptor

1.3.5.1 succinate dehydrogenase

1.3.5.2 dihydroorotate dehydrogenase (quinone)

1.3.5.3 protoporphyrinogen IX dehydrogenase (quinone)

1.3.5.4 fumarate reductase (quinol)

1.3.5.5 15-cis-phytoene desaturase

1.3.5.6 9,9′-dicis-ζ-carotene desaturase

1.3.7 With an iron-sulfur protein as acceptor

1.3.8 With a flavin as acceptor

1.3.98 With other, known, physiological acceptors

1.3.99 With unknown physiological acceptors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.23.1 With NADH or NADPH as donor

1.23.5 With a quinone or similar compound as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)