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EC 1.1.1.312 Details
show Brenda entryEC number
1.1.1.312
Accepted name
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Reaction
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ = 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+
Other name(s)
2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase,
4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase,
α-hydroxy-γ-carboxymuconic ε-semialdehyde dehydrogenase,
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase,
LigC,
ProD
Systematic name
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase
Comment
The enzyme does not act on unsubstituted aliphatic or aromatic aldehydes or glucose; NAD+ can replace NADP+, but with lower affinity. The enzyme was initially believed to act on 4-carboxy-2-hydroxy-cis,cis-muconate 6-semialdehyde and produce 4-carboxy-2-hydroxy-cis,cis-muconate [1]. However, later studies showed that the substrate is the hemiacetal form [3], and the product is 2-oxo-2H-pyran-4,6-dicarboxylate [2,4].
History
created 1978 as EC 1.2.1.45, transferred 2011 to EC 1.1.1.312
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.10.3.7 created 1986, deleted 2002 1.10.3.8 created 1986, deleted 2002
