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EC 2.7.7.86 Details
EC number
2.7.7.86
Accepted name
cyclic GMP-AMP synthase
Reaction
ATP + GTP = 2 diphosphate + cyclic Gp(2′-5′)Ap(3′-5′) (overall reaction);;(1a) ATP + GTP = pppGp(2′-5′)A + diphosphate;;(1b) pppGp(2′-5′)A = cyclic Gp(2′-5′)Ap(3′-5′) + diphosphate
Other name(s)
cGAMP synthase, cGAS
Systematic name
ATP:GTP adenylyltransferase (cyclizing)
Comment
Cyclic Gp(2′-5′)Ap(3′-5′) is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
History
created 2013, modified 2014
EC Tree
1.2.7.9 created 2003, deleted 2005