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EC 4.3.1.28 Details
EC number
4.3.1.28
Accepted name
L-lysine cyclodeaminase
Reaction
L-lysine = L-pipecolate + NH3
Other name(s)
rapL (gene name),
fkbL (gene name),
tubZ (gene name),
visC (gene name)
Systematic name
L-lysine ammonia-lyase (cyclizing; ammonia-forming)
Comment
Requires bound NAD+. The enzyme produces the non-proteinogenic amino acid L-pipecolate, which is incorporated into multiple secondary metabolite products, including rapamycin, tobulysin, virginiamycin and pristinamycin.
History
created 2012
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