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EC 4.1.3.43 Details
show Brenda entryEC number
4.1.3.43
Accepted name
4-hydroxy-2-oxohexanoate aldolase
Reaction
(S)-4-hydroxy-2-oxohexanoate = propanal + pyruvate
Other name(s)
BphI
Systematic name
(S)-4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)
Comment
Requires Mn2+ for maximal activity [1,2]. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase [1,2,6]. The enzyme forms a bifunctional complex with EC 1.2.1.87, propanal dehydrogenase (CoA-propanoylating), with a tight channel connecting the two subunits [3,4,6].
History
created 2013
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.13.12.10 created 1989, modified 1999, deleted 2001
