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EC 1.13.11.46 Details

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EC number

1.13.11.46

Accepted name

4-hydroxymandelate synthase

Reaction

4-hydroxyphenylpyruvate + O₂ = (S)-4-hydroxymandelate + CO₂

Other name(s)

4-hydroxyphenylpyruvate dioxygenase II

Systematic name

(S)-4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)

CAS registry number

280566-04-3

Comment

Requires Fe²⁺. Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.

History

created 2001

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.12.1 With NAD⁺ or NADP⁺ as acceptor

1.12.2 With a cytochrome as acceptor

1.12.5 With a quinone or similar compound as acceptor

1.12.7 With an iron-sulfur protein as acceptor

1.12.98 With other, known, physiological acceptors

1.12.99 With unknown physiological acceptors

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.1. undefined

1.13.11 With incorporation of two atoms of oxygen

1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

1.13.12.1 arginine 2-monooxygenase

1.13.12.2 lysine 2-monooxygenase

1.13.12.3 tryptophan 2-monooxygenase

1.13.12.4 lactate 2-monooxygenase

1.13.12.5 Renilla-type luciferase

1.13.12.6 Cypridina-luciferin 2-monooxygenase

1.13.12.7 firefly luciferase

1.13.12.8 Watasenia-luciferin 2-monooxygenase

1.13.12.9 phenylalanine 2-monooxygenase

1.13.12.10 created 1989, modified 1999, deleted 2001

1.13.12.11 methylphenyltetrahydropyridine N-monooxygenase

1.13.12.12 apo-β-carotenoid-14′,13′-dioxygenase

1.13.12.13 Oplophorus-luciferin 2-monooxygenase

1.13.12.14 chlorophyllide-a oxygenase

1.13.12.15 3,4-dihydroxyphenylalanine oxidative deaminase

1.13.12.16 nitronate monooxygenase

1.13.12.17 dichloroarcyriaflavin A synthase

1.13.12.18 dinoflagellate luciferase

1.13.12.19 2-oxoglutarate dioxygenase (ethene-forming)

1.13.12.20 noranthrone monooxygenase

1.13.12.21 tetracenomycin-F1 monooxygenase

1.13.12.22 deoxynogalonate monooxygenase

1.13.12.23 4-hydroxy-3-prenylbenzoate synthase

1.13.12.24 calcium-regulated photoprotein

1.13.99 Miscellaneous

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups

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Release 2023.1 (January 2023)