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EC 4.7.1.1 Details
EC number
4.7.1.1
Accepted name
α-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase
Reaction
α-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + reduced electron acceptor = α-D-ribose 1,2-cyclic phosphate 5-phosphate + methane + L-methionine + 5′-deoxyadenosine + oxidized electron acceptor
Other name(s)
phnJ (gene name)
Systematic name
α-D-ribose-1-methylphosphonate-5-phosphate C-P-lyase (methane-forming)
Comment
This radical SAM (AdoMet) enzyme is part of the C-P lyase complex, which is responsible for processing phophonates into usable phosphate. Contains an [4Fe-4S] cluster. The enzyme from the bacterium Escherichia coli can act on additional α-D-ribose phosphonate substrates with different substituents attached to the phosphonate phosphorus (e.g. α-D-ribose-1-[N-(phosphonomethyl)glycine]-5-phosphate and α-D-ribose-1-(2-N-acetamidomethylphosphonate)-5-phosphate).
History
created 2013, modified 2016
EC Tree
1.13.11.7 created 1965 as EC 1.13.1.7, transferred 1972 to EC 1.13.11.7, deleted 1980
1.13.11.21 created 1972, deleted 2001