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EC 2.7.11.30 Details
EC number
2.7.11.30
Accepted name
receptor protein serine/threonine kinase
Reaction
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Other name(s)
activin receptor kinase,
receptor type I serine/threonine protein kinase,
receptor type II serine/threonine protein kinase,
STK13,
TGF-&beta,
kinase,
receptor serine/threonine protein kinase
Systematic name
ATP:[receptor-protein] phosphotransferase
Comment
The transforming growth factor β (TGF-β) family of cytokines regulates cell proliferation, differentiation, recognition and death. Signalling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. Bound TGF-β is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates [1,3].
History
created 2005 (EC 2.7.1.37 part-incorporated 2005)
EC Tree
1.13.11.7 created 1965 as EC 1.13.1.7, transferred 1972 to EC 1.13.11.7, deleted 1980
1.13.11.21 created 1972, deleted 2001