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EC 2.7.8.13 Details
EC number
2.7.8.13
Accepted name
phospho-N-acetylmuramoyl-pentapeptide-transferase
Reaction
UDP-Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
Other name(s)
MraY transferase,
UDP-MurNAc-L-Ala-D-γ-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase,
UDP-MurNAc-Ala-γDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase,
phospho-N-acetylmuramoyl pentapeptide translocase,
phospho-MurNAc-pentapeptide transferase,
phospho-NAc-muramoyl-pentapeptide translocase (UMP),
phosphoacetylmuramoylpentapeptide translocase,
phosphoacetylmuramoylpentapeptidetransferase
Systematic name
UDP-MurAc(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase
CAS registry number
9068-50-2
Comment
In Gram-negative and some Gram-positive organisms the L-lysine is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm), which is combined with adjacent residues through its L-centre. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here).
History
created 1972, modified 2002
EC Tree
1.12.7.1 created 1972, deleted 1978