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EC 1.2.1.27 Details
EC number
1.2.1.27
Accepted name
methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
Reaction
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH
Other name(s)
MSDH, MMSA dehydrogenase, iolA (gene name), methylmalonate-semialdehyde dehydrogenase (acylating)
Systematic name
2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)
CAS registry number
37205-49-5
Comment
Also converts 3-oxopropanoate into acetyl-CoA [3]. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding [3]. Bicarbonate rather than CO2 is released as a final product [3].
History
created 1972, modified 2014
EC Tree
1.2.1.1 created 1961, modified 1982, modified 2002, deleted 2005
1.2.1.6 created 1961, deleted 1965
1.2.1.14 created 1961, deleted 1984
1.2.1.34 created 1972, deleted 1983 [transferred to EC 1.1.1.180, deleted 1984]
1.2.1.35 created 1972, deleted 1984
1.2.1.37 created 1972, deleted 1984
1.2.1.55 created 1990, deleted 2003
1.2.1.56 created 1990, deleted 2003