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EC 1.21.3.3 Details
EC number
1.21.3.3
Accepted name
reticuline oxidase
Reaction
(S)-reticuline + O2 = (S)-scoulerine + H2O2
Other name(s)
BBE, berberine bridge enzyme, berberine-bridge-forming enzyme, tetrahydroprotoberberine synthase
Systematic name
(S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming)
CAS registry number
152232-28-5
Comment
Contains FAD. The enzyme from the plant Eschscholtzia californica binds the cofactor covalently [3]. Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge (’berberine bridge’) of (S)-tetrahydroprotoberberines. The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants.
History
created 1989 as EC 1.5.3.9, transferred 2002 to EC 1.21.3.3
EC Tree
1.97.1.5 created 2000 deleted 2001
1.97.1.6 created 2000 deleted 2001
1.97.1.7 created 2000, deleted 2001