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EC 1.11.1.8 Details
EC number
1.11.1.8
Accepted name
iodide peroxidase
Reaction
(1) 2 iodide + H2O2 + 2 H+ = diiodine + 2 H2O;;(2) [thyroglobulin]-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3-iodo-L-tyrosine + 2 H2O;;(3) [thyroglobulin]-3-iodo-L-tyrosine + iodide + H2O2 = [thyroglobulin]-3,5-diiodo-L-tyrosine + 2 H2O;;(4) 2 [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-L-thyroxine + [thyroglobulin]-aminoacrylate + 2 H2O;;(5) [thyroglobulin]-3-iodo-L-tyrosine + [thyroglobulin]-3,5-diiodo-L-tyrosine + H2O2 = [thyroglobulin]-3,5,3′-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate + 2 H2O
Other name(s)
thyroid peroxidase, iodoperoxidase (heme type), iodide peroxidase-tyrosine iodinase, thyroperoxidase, tyrosine iodinase, TPO, iodinase
Systematic name
iodide:hydrogen-peroxide oxidoreductase
CAS registry number
9031-28-1
Comment
Thyroid peroxidase catalyses the biosynthesis of the thyroid hormones L-thyroxine and triiodo-L-thyronine. It catalyses both the iodination of tyrosine residues in thyroglobulin (forming mono- and di-iodinated forms) and their coupling to form either L-thyroxine or triiodo-L-thyronine.
History
created 1961, modified 2012
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