EC Explorer

1.1.1.352

5′-hydroxyaverantin dehydrogenase

(1) (1′S,5′S)-hydroxyaverantin + NAD⁺ = 5′-oxoaverantin + NADH + H⁺;;(2) (1′S,5′R)-hydroxyaverantin + NAD⁺ = 5′-oxoaverantin + NADH + H⁺

HAVN dehydrogenase, adhA (gene name)

(1′S,5′S)-hydroxyaverantin:NAD⁺ oxidoreductase

Isolated from the aflatoxin-producing mold Aspergillus parasiticus [2]. Involved in aflatoxin biosynthesis. 5′-Oxoaverantin will spontaneously form averufin by intramolecular ketalisation. cf. EC 4.2.1.142, 5′-oxoaverantin cyclase.

created 2013