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EC 1.10.99.2 Details
EC number
1.10.99.2
Accepted name
ribosyldihydronicotinamide dehydrogenase (quinone)
Reaction
1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(β-D-ribofuranosyl)nicotinamide + a hydroquinone
Other name(s)
NRH:quinone oxidoreductase 2, NQO2, NAD(P)H:quinone oxidoreductase-2 (misleading), QR2, quinone reductase 2, N-ribosyldihydronicotinamide dehydrogenase (quinone), NAD(P)H:quinone oxidoreductase2 (misleading)
Systematic name
1-(β-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase
CAS registry number
667919-86-0
Comment
A flavoprotein. Unlike EC 1.6.5.2, NAD(P)H dehydrogenase (quinone), this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the oestrogens 17β-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor [2]. This enzyme can catalyse both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced [3].
History
created 2005, deleted 2014
EC Tree
1.11.1.4 created 1961, deleted 1964, reinstated 1965 as EC 1.13.1.12, deleted 1972