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EC 1.14.12.22 Details
EC number
1.14.12.22
Accepted name
carbazole 1,9a-dioxygenase
Reaction
9H-carbazole + NAD(P)H + H+ + O2 = 2′-aminobiphenyl-2,3-diol + NAD(P)+
Other name(s)
CARDO
Systematic name
9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating)
Comment
This enzyme catalyses the first reaction in the pathway of carbazole degradation. The enzyme attacks at the 1 and 9a positions of carbazole, resulting in the formation of a highly unstable hemiaminal intermediate that undergoes a spontaneous cleavage and rearomatization, resulting in 2′-aminobiphenyl-2,3-diol. In most bacteria the enzyme is a complex composed of a terminal oxygenase, a ferredoxin, and a ferredoxin reductase. The terminal oxygenase component contains a nonheme iron centre and a Rieske [2Fe-2S] iron-sulfur cluster.
History
created 2010
EC Tree
1.3.1.23 created 1972, deleted 2005
1.3.1.50 created 1992, deleted 1999
1.3.1.55 created 1999, deleted 2004