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EC 4.2.3.152 Details
EC number
4.2.3.152
Accepted name
2-epi-5-epi-valiolone synthase
Reaction
α-D-sedoheptulopyranose 7-phosphate = 2-epi-5-epi-valiolone + phosphate
Other name(s)
AcbC, ValA, CetA, SalQ, C7-cyclitol synthase
Systematic name
α-D-sedoheptulopyranose-7-phosphate phosphate-lyase (cyclizing; 2-epi-5-epi-valiolone-forming)
Comment
The enzyme is highly specific for α-D-sedoheptulopyranose 7-phosphate. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. The enzyme is involved in the biosynthesis of C7N-aminocyclitol natural products, such as the valienamine moiety of the antidiabetic drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.155, 2-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.
History
created 2015, modified 2016
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