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EC 1.13.11.42 Details

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EC number

1.13.11.42

Accepted name

indoleamine-pyrrole 2,3-dioxygenase

Reaction

L-tryptophan + O₂ = N-formylkynurenine

Other name(s)

indoleamine 2,3-dioxygenase

Systematic name

indoleamine:oxygen 2,3-dioxygenase (indole-decyclizing)

CAS registry number

9014-51-1

Comment

Acts on many substituted and unsubstituted indoleamines, including melatonin. Involved in the degradation of melatonin.

History

created 1992, deleted 2006

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.1. undefined

1.13.11 With incorporation of two atoms of oxygen

1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases)

1.13.12.1 arginine 2-monooxygenase

1.13.12.2 lysine 2-monooxygenase

1.13.12.3 tryptophan 2-monooxygenase

1.13.12.4 lactate 2-monooxygenase

1.13.12.5 Renilla-type luciferase

1.13.12.6 Cypridina-luciferin 2-monooxygenase

1.13.12.7 firefly luciferase

1.13.12.8 Watasenia-luciferin 2-monooxygenase

1.13.12.9 phenylalanine 2-monooxygenase

1.13.12.10 created 1989, modified 1999, deleted 2001

1.13.12.11 methylphenyltetrahydropyridine N-monooxygenase

1.13.12.12 apo-β-carotenoid-14′,13′-dioxygenase

1.13.12.13 Oplophorus-luciferin 2-monooxygenase

1.13.12.14 chlorophyllide-a oxygenase

1.13.12.15 3,4-dihydroxyphenylalanine oxidative deaminase

1.13.12.16 nitronate monooxygenase

1.13.12.17 dichloroarcyriaflavin A synthase

1.13.12.18 dinoflagellate luciferase

1.13.12.19 2-oxoglutarate dioxygenase (ethene-forming)

1.13.12.20 noranthrone monooxygenase

1.13.12.21 tetracenomycin-F1 monooxygenase

1.13.12.22 deoxynogalonate monooxygenase

1.13.12.23 4-hydroxy-3-prenylbenzoate synthase

1.13.12.24 calcium-regulated photoprotein

1.13.99 Miscellaneous

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)