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EC 4.3.1.30 Details
show Brenda entryEC number
4.3.1.30
Accepted name
dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
Reaction
dTDP-4-amino-4,6-dideoxy-α-D-glucopyranose + S-adenosyl-L-methionine + reduced acceptor = dTDP-3-dehydro-4,6-dideoxy-α-D-glucopyranose + NH3 + L-methionine + 5′-deoxyadenosine + acceptor
Other name(s)
desII (gene name),
eryCV (gene name),
MegCV
Systematic name
dTDP-4-amino-4,6-dideoxy-α-D-glucopyranose ammonia lyase (dTDP-3-dehydro-4,6-dideoxy-α-D-glucopyranose-forming)
Comment
The enzyme, which is a member of the ’AdoMet radical’ (radical SAM) family, is involved in biosynthesis of TDP-α-D-desosamine. The reaction starts by the transfer of an electron from the reduced form of the enzyme’s [4Fe-4S] cluster to S-adenosyl-L-methionine, spliting it into methionine and the radical 5-deoxyadenosin-5′-yl, which attacks the sugar substrate.
History
created 2011
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.2.1 created 1961, deleted 1965 1.6.2.3 created 1972, deleted 1965 1.13.11.21 created 1972, deleted 2001
