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EC 2.7.11.29 Details
show Brenda entryEC number
2.7.11.29
Accepted name
low-density-lipoprotein receptor kinase
Reaction
ATP + [low-density-lipoprotein receptor]-L-serine = ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine
Other name(s)
ATP:low-density-lipoprotein-L-serine O-phosphotransferase,
LDL receptor kinase,
[low-density-lipoprotein] kinase,
low-density lipoprotein kinase,
low-density-lipoprotein receptor kinase (phosphorylating),
STK7
Systematic name
ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase
CAS registry number
107445-00-1
Comment
Phosphorylates the last serine residue (Ser-833) in the cytoplasmic domain of the low-density lipoprotein receptor from bovine adrenal cortex. Casein can also act as a substrate but with lower affinity. GTP can act instead of ATP.
History
created 1990 as EC 2.7.1.131, transferred 2005 to EC 2.7.11.29
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1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.6.2.1 created 1961, deleted 1965 1.6.2.3 created 1972, deleted 1965 1.13.11.21 created 1972, deleted 2001
