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EC 1.6.99.6 Details

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EC number

1.6.99.6

Accepted name

NADPH dehydrogenase (quinone)

Reaction

NADPH + H⁺ + acceptor = NADP⁺ + reduced acceptor

Other name(s)

reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase, NADPH oxidase, NADPH₂ dehydrogenase (quinone)

Systematic name

NADPH:(quinone-acceptor) oxidoreductase

CAS registry number

37256-37-4

Comment

A flavoprotein. Menaquinone can act as acceptor. Inhibited by dicoumarol and folic acid derivatives but not by 2,4-dinitrophenol.

History

created 1972, deleted 2011

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.7.1 With NAD⁺ or NADP⁺ as acceptor

1.7.2 With a cytochrome as acceptor

1.7.3 With oxygen as acceptor

1.7.3.1 nitroalkane oxidase

1.7.3.2 acetylindoxyl oxidase

1.7.3.3 factor-independent urate hydroxylase

1.7.3.4 hydroxylamine oxidase

1.7.3.5 3-aci-nitropropanoate oxidase

1.7.3.6 hydroxylamine oxidase (cytochrome)

1.7.5 With a quinone or similar compound as acceptor

1.7.6 With a nitrogenous group as acceptor

1.7.7 With an iron-sulfur protein as acceptor

1.7.9 With a copper protein as acceptor

1.7.99 With unknown physiological acceptors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)