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EC 2.7.11.25 Details
EC number
2.7.11.25
Accepted name
mitogen-activated protein kinase kinase kinase
Reaction
ATP + a protein = ADP + a phosphoprotein
Other name(s)
cMos, cRaf, MAPKKK, MAP3K, MAP kinase kinase kinase, MEKK, MEKK1, MEKK2, MEKK3, MEK kinase, Mil/Raf, MLK-like mitogen-activated protein triple kinase, MLTK, MLTKa, MLTKb, REKS, STK28
Systematic name
ATP:protein phosphotransferase (MAPKKKK-activated)
CAS registry number
146702-84-3
Comment
This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
created 2005 (EC 2.7.1.37 part-incorporated 2005)
EC Tree
1.6.2.1 created 1961, deleted 1965
1.6.2.3 created 1972, deleted 1965
1.7.1.8 created 2002, deleted 2002