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EC 1.3.99.16 Details

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EC number

1.3.99.16

Accepted name

isoquinoline 1-oxidoreductase

Reaction

isoquinoline + acceptor + H₂O = isoquinolin-1(2H)-one + reduced acceptor

Systematic name

isoquinoline:acceptor 1-oxidoreductase (hydroxylating)

CAS registry number

155948-73-5

Comment

The enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate.

History

created 1999

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.1.1 alanine dehydrogenase

1.4.1.2 glutamate dehydrogenase

1.4.1.3 glutamate dehydrogenase [NAD(P)⁺]

1.4.1.4 glutamate dehydrogenase (NADP⁺)

1.4.1.5 L-amino-acid dehydrogenase

1.4.1.6 created 1961, deleted 1982

1.4.1.7 serine 2-dehydrogenase

1.4.1.8 valine dehydrogenase (NADP⁺)

1.4.1.9 leucine dehydrogenase

1.4.1.10 glycine dehydrogenase

1.4.1.11 L-erythro-3,5-diaminohexanoate dehydrogenase

1.4.1.12 2,4-diaminopentanoate dehydrogenase

1.4.1.13 glutamate synthase (NADPH)

1.4.1.14 glutamate synthase (NADH)

1.4.1.15 lysine dehydrogenase

1.4.1.16 diaminopimelate dehydrogenase

1.4.1.17 N-methylalanine dehydrogenase

1.4.1.18 lysine 6-dehydrogenase

1.4.1.19 tryptophan dehydrogenase

1.4.1.20 phenylalanine dehydrogenase

1.4.1.21 aspartate dehydrogenase

1.4.1.22 ornithine cyclodeaminase

1.4.1.23 valine dehydrogenase (NAD⁺)

1.4.1.24 3-dehydroquinate synthase II

1.4.1.25 L-arginine dehydrogenase

1.4.1.26 2,4-diaminopentanoate dehydrogenase (NAD⁺)

1.4.1.27 glycine cleavage system

1.4.1.28 secondary-alkyl amine dehydrogenase [NAD(P)⁺]

1.4.2 With a cytochrome as acceptor

1.4.3 With oxygen as acceptor

1.4.4 With a disulfide as acceptor

1.4.5 With a quinone or other compound as acceptor

1.4.7 With an iron-sulfur protein as acceptor

1.4.9 With a copper protein as acceptor

1.4.98. undefined

1.4.99 With unknown physiological acceptors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.6.1 With NAD⁺ or NADP⁺ as acceptor

1.6.2 With a heme protein as acceptor

1.6.2.1 created 1961, deleted 1965

1.6.2.2 cytochrome-b₅ reductase

1.6.2.3 created 1972, deleted 1965

1.6.2.4 NADPH—hemoprotein reductase

1.6.2.5 NADPH—cytochrome-c₂ reductase

1.6.2.6 leghemoglobin reductase

1.6.3 With oxygen as acceptor

1.6.4 With a disulfide as acceptor (deleted sub-subclass)

1.6.5 With a quinone or similar compound as acceptor

1.6.6 With a nitrogenous group as acceptor

1.6.7 With an iron-sulfur protein as acceptor (deleted sub-subclass)

1.6.8 With a flavin as acceptor (deleted sub-subclass)

1.6.99 With unknown physiological acceptors

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.1 With NAD⁺ or NADP⁺ as acceptor

1.21.3 With oxygen as acceptor

1.21.4 With a disulfide as acceptor

1.21.98 With other, known, physiological acceptors

1.21.99 With unknown physiological acceptors

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

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Release 2023.1 (January 2023)